This is significant: Louisiana Democrat Takes House Seat

From The New York Times:

A Democrat took an open Congressional seat long held by Republicans in the conservative district around Baton Rouge in a special election Saturday, giving the party an early boost in its quest for an increased majority in the House of Representatives.

[The Democratic victor overcame] the Republicans’ depiction of him as a “liberal” in lock step with figures like the House speaker, Nancy Pelosi, and Senator Barack Obama, who shared billing with him in a barrage of Republican attack advertisements.

The two parties saw the Louisiana race as an important test for the fall, given how safe the district has been for Republicans for more than three decades. Democrats viewed a potential victory as a measure of Republican vulnerability; Republicans saw it as an indication of how difficult it might be to defend more than two dozen open seats in play in November.
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The Washington Post noted:

A Louisiana Democrat captured a House seat held by Republicans for the previous 33 years . . . in a special election that Republicans tried to turn into a referendum on Sen. Barack Obama (D-Ill.).